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I think I found the issue. As I mentioned in a comment above, I installed Webmin after OSSEC. It looks like the cause of OSSEC using such a big amount of disk space is the Webmin system status (which is updated all the time).
I added the corresponding folder to the ignore list of OSSEC and it seems it solved the issue.
<ignore>/etc/webmin/system-status</ignore>
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Thanks @finid for the many answers.