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I had to go refresh my internet lingo, if by hotlink you mean that you would like to embed an image or video file from spaces from within your own site (for example mydomain.com) you will need to update CORS policies, and you should also enable CDN for SPEED!
Set CORS policies to allow embedding of content from your domain. https://www.digitalocean.com/docs/spaces/how-to/cors/ - you will want to add your exact domain including subdomain and HTTP/HTTPS https://www.mydomain.com and check the GET box
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