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Hello.
In case you are upgrading your Droplet, there should be no configuration changes lost as this would essentially mean that you are only adding extra resources to the Droplet.
The downtime from resizing varies depending on how much disk is in use. This is true even when only resizing CPU and RAM only because the Droplet may move to a new hypervisor, which transfers disk data over the network.
For more information you could check out the official documentation here:
https://www.digitalocean.com/docs/droplets/how-to/resize/
Hope that this helps! Regards, Bobby