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What is your droplet size?
One of possibilities is that MySQL servers gets killed for some reason. For example that can be due to sufficient memory.
For beginning I would verify syslog for Out Of Memory killer logs.
Open /var/log/syslog with your favorite text editor:
- nano /var/log/syslog
Look thought it and if you see Out of memory killer logs. If you see any OOM messages there, that means your droplet needs more memory to run killed process (e.g. MySQL). In that case, I can recommend adding Swap to your droplet or resizing it to bigger one. If this is not the case, we can try looking for MySQL logs, but this is what I would first check. :)