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Hi @juanfer,
You should use www-data for all your websites for both user and group. Those are the default Apache ownerships. You can check that in the following file
/etc/apache2/envvars
Anyway, on to your problem. Usually, websites can run with the root:root in such cases however most often than not they experience issues running to logs, opening other files etc. when using the root:root ownership.
What I suggest is to try and use www-data everywhere(only for the domain’s folder!) and see if the issue is still going to be experienced. If it’s still experienced checked your Apache error logs for more detailed explanation as to why it’s showing errors.
Regards, KFSys