We need some more information, also Zoho requires the use of SSL when connecting. What kind of application or environment? You might not be using SSL in your connection.
What error are you receiving? you need to test port 465 availability like this
$ openssl s_client -starttls smtp -crlf -connect 204.141.24.118:465
CONNECTED(00000003)
Regarrrrrrrrrrds, pyrate ;0
Hello Guys, I have the same problem. I'm trying send e-mail from my application (PHPMailer) :
# telnet smtp.zoho.com 465
Time Out
# openssl s_client -starttls smtp -crlf -connect 8.40.222.118:465
connect:errno=9
Same issue here. Can't ping or send emails via Zoho SMTP. This is a big issue and has been troubling us since weeks. Most probably digitalocean has blocked outgoing mails via Zoho..