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Pretty simple, but you’ll need to handle the coding part.
Example vhost config (written for CentOS 6.6)
<VirtualHost *:80>
ServerName users.your-domain.com
ServerAlias *.users.your-domain.com
#### This is where you put your files for that domain: /var/www/vhosts/c.jonsjava.com
DocumentRoot /var/www/vhosts/users.your-domain.com/
<Directory /var/www/vhosts/users.your-domain.com>
# This section sets directives for the directory.
# -Indexes <-- That blocks index listings on folders that don't have a default file (index.php/index.html/default.html/etc)
# FollowSymLinks <-- This will treat symlinks like they should be treated in linux: as folders/files in the folder the symlink resides
# MultiViews <--It's easier for you to read this: http://httpd.apache.org/docs/2.0/content-negotiation.html#multiviews
Options -Indexes FollowSymLinks MultiViews
# AllowOverride All <-- This is required for Apache HTTPD server to read .htaccess files. It says that you can have a per-folder override for apache directives
AllowOverride All
</Directory>
## Everything to see here. Just the log files. Good to use for troubleshooting errors.
CustomLog /var/log/httpd/users.your-domain.com-access.log combined
ErrorLog /var/log/httpd/users.your-domain.com-error.log
# Possible values include: debug, info, notice, warn, error, crit,
# alert, emerg.
LogLevel warn
</VirtualHost>
$URL = $_SERVER[SERVER_NAME];
$user= str_replace(".users.your-domain.com","",$URL);
Now, you have the user. Just have your code configured to show that users page, or a 404 if it doesn’t exist.