Build a new list with a list comprehension:

new_items = [x if x % 2 else None for x in items]

You can modify the original list in-place if you want, but it doesn’t actually save time:

items = [0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10]
for index, item in enumerate(items):
    if not (item % 2):
        items[index] = None

Here are (Python 3.6.3) timings demonstrating the non-timesave:

In [1]: %%timeit
   ...: items = [0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10]
   ...: for index, item in enumerate(items):
   ...:     if not (item % 2):
   ...:         items[index] = None
   ...:
1.06 µs ± 33.7 ns per loop (mean ± std. dev. of 7 runs, 1000000 loops each)

In [2]: %%timeit
   ...: items = [0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10]
   ...: new_items = [x if x % 2 else None for x in items]
   ...:
891 ns ± 13.6 ns per loop (mean ± std. dev. of 7 runs, 1000000 loops each)

And Python 2.7.6 timings:

In [1]: %%timeit
   ...: items = [0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10]
   ...: for index, item in enumerate(items):
   ...:     if not (item % 2):
   ...:         items[index] = None
   ...: 
1000000 loops, best of 3: 1.27 µs per loop
In [2]: %%timeit
   ...: items = [0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10]
   ...: new_items = [x if x % 2 else None for x in items]
   ...: 
1000000 loops, best of 3: 1.14 µs per loop

@stiltonwalrus432

@MattIPv4 is right, we need a little more detail unless that cut/paste from stack over flow above helps you…