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Hi @mrsreez,
What you could do is set up an Apache reverse proxy for this particular domain. That way you would not have to type the port specifically each time.
You can follow the steps here on how to set up a reverse proxy for Apache:
One important thing to keep in mind is, as you are using Plesk, you need to make sure that you follow the steps described here in order to correctly edit your Virtual Host configuration file:
https://docs.plesk.com/en-US/obsidian/advanced-administration-guide-linux/72064/
Another thing to try is to follow the steps from the official Plesk documentation on how to install Django applications on Plesk:
Hope that this helps! Let me know if you have any questions. Regards, Bobby