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You create an A-Record in your DNS panel that points to the desired IP address.
What you need to do is setup proxying. This can be done with Apache using mod_proxy and there’s a guide for exactly that here at DigitalOcean.
Without using a proxy, which internally accepts requests for domain.com or sub.domain.com and serves domain.com:2365 (or any application running on a port, just an example), you’d need to keep the ports in the URL’s.