Is it mandatory the use of the Digital Ocean's DNS for each record when handling multiple domains/subdomains on a single droplet?

Hi,

I’ve read different post on the Digital Ocean’s Forums and still I have not clear how the setup for multiple domain works in here.

If I setup a droplet for handle multiple domains, is the apache vHost enough to handle the request or is it mandatory to set it up every single domain /sub-domain also on the Digital Ocean DNS server.

I’m asking because I have my Vanity NS pointed to the Digital Ocean’s NS and the main domain resolves ok but the sub-domains no, and I have double checked and the sub-domains are set properly on the vHost.

Also I know using a WildCard like [*.mysite.com] is an alternative on the Digital Ocean’s DNS panel but at the same time I don’t know how it migth affect the resolution of the vanity NS1.mysite.com, NS2.mysite.com and NS3.mysite.com