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What you’d want to do is use alias in your /panel location block, which will allow you to define a new location for this specific block.
For example, you’re web root is:
/home/example.com/public
… and your ./panel location is:
/home/example.com/panel
… so you could use alias inside the panel location block like so:
location /panel {
alias /home/example.com/panel;
}
Once changes are made, you’d simply reload NGINX to allow the changes to take.
systemctl reload nginx
or
service nginx reload