This is definitely possible. It can be implemented by setting up separate server blocks for each app. Check out this tutorial:

• How To Set Up Nginx Server Blocks (Virtual Hosts) on Ubuntu 14.04 LTS

At its most basic, you can create a separate block for each. This uses the server_name directive to route requests to example.com to your php app and requests to node.example.com to the node app running on port 2368.

server {
    listen 80 default_server;
    listen [::]:80 default_server ipv6only=on;

    root /usr/share/nginx/html/php;
    index index.php index.html index.htm;

    server_name example.com;

    location / {
        try_files $uri $uri/ =404;
    }

    error_page 404 /404.html;
    error_page 500 502 503 504 /50x.html;
    location = /50x.html {
        root /usr/share/nginx/html;
    }

    location ~ \.php$ {
        try_files $uri =404;
        fastcgi_split_path_info ^(.+\.php)(/.+)$;
        fastcgi_pass unix:/var/run/php5-fpm.sock;
        fastcgi_index index.php;
        fastcgi_param SCRIPT_FILENAME $document_root$fastcgi_script_name;
        include fastcgi_params;
    }
}

server {
    listen 80;
    listen [::]:80 ipv6only=on;

    server_name node.example.com;

    root /usr/share/nginx/html/node;
    index index.html index.htm;

    client_max_body_size 10G;

    location / {
        proxy_pass http://localhost:2368;
        proxy_set_header X-Forwarded-For $proxy_add_x_forwarded_for;
        proxy_set_header Host $http_host;
        proxy_set_header X-Forwarded-Proto $scheme;
        proxy_buffering off;
    } 
}

If you need to do something a little more complicate, you might also want to check out:

• Understanding Nginx Server and Location Block Selection Algorithms

Thanks! But I already figured it out 2 days ago. :)

Hey,
I got error like this
Starting nginx: nginx: [emerg] duplicate listen options for [::]:80 in /var/www/hosts/librarian.conf:32

Check this Gist… it works for me ;)

Practically you can copy and paste, just need to update the routes.

https://gist.github.com/yacafx/a730903e8ec69063c18394e4752b6657

Hope this works for you!