I am sure someone has answered this by now or you have found what you're looking for because it was so long ago but the answer lies in what you're trying to do. I think using Spring Boot is easier and more feature-rich than Jersey and Guice. If you just need a REST-ful web service with little dependencies then I guess you could use Jersey. Although there is more configuration with the DI container (Guice), setting up your embedded servlet container/HTTP server, and then implementing your data access layer (if there is one). Whereas in the Spring ecosystem I have REST/JSON/XML services built in, a full blown web MVC framework built in, Spring-Data for data access, embedded Tomcat, Jetty, or UnderTow ready to go. Metrics and healthchecks, cloud connectors for remote services and cloud environments. So if it were me I would just go with Spring Boot so that I have the option to add features and have so much set up for me already. Oh yeah, Integration and Batch operations, email out of the box, the list goes on.