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Hi there,
There are no restrictions on the DigitalOcean side, you can spin up a WordPress Droplet and then create a Managed Postgres Cluster.
With the DigitalOcean Droplets you do have root access, so you will be able to make all of the necessary changes that you need and install any additional packages that might be required.
However, there are a few things to keep in mind according to the official WordPress documentation:
I would personally stick to MySQL due to the technical debt that might come after implementing Postgres, but I will be very curious to hear why you need to use Postgres with WordPress?
With other PHP frameworks like Laravel, both Postgres and MySQL are natively supported, but with WordPress, it might be a challenge.
Hope that this helps!
Best,
Bobby