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Hello, First of all it is not a good idea to setup ISPConfig on a server that already has services running and configured, but you already knew this. From your question you understand you have manually added the VHOSTs for site1.com and site2.com. If you haven’t got any connection problems, this isn’t a big deal. You can keep this configuration and just add new domains/sites threw ISPConfig. ISPConfig will not touch the default VHOST, it only creates new configurations with the same name as the domain of the site.
Ofcourse if you want to organize everything, and keep it all managed at one point; best thing would be to remove the site from your VHOST files and backup and remove the site folders. After this you can re-create it threw ISPConfig.
To change the control panel domain, you can edit the ispconfig.vhost file.