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I have a similar problem using https://github.com/ctrox/csi-s3, since it states The provided 'x-amz-content-sha256' header does not match what was computed, it seems that the API is not 100% compatible with S3 API.
I’ve found that DigitalOcean Spaces does not like signed payloads, which is the default when using things like the AWS PHP SDK v3.
So as well as setting “endpoint”, also set “signature_version” to “v4-unsigned-body”.