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There’s really no limit as to what you can use to build your site. DigitalOcean provides barebones VPS (Droplets) which allow you to install the software you need to power your site. Typically, you’ll start with either a LAMP or LEMP Stack and build from there.
LAMP Stack
Ubuntu 16.04 LTS, Apache, MariaDB/MySQL, and PHP (using mod_php)
LEMP Stack
Ubuntu 16.04 LTS, NGINX, MariaDB/MySQL, and PHP-FPM
…
From there you can use WordPress, Joomla, Drupal, Laravel, or any other application or framework to build out your website.