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The great part is you can really run it from wherever you like, it just depends on some tweak to configuration. You could change permissions to run it in /opt, or you could have it run from /home/user instead and change the configuration to have it recognize it is stemming from there. It all depends on how you want to do it!
Me personally, I don’t like running my node.js applications from /opt. I like running things from my user’s HOMEDIR or somewhere within /var
Hope it helps, Jason Colyer DigitalOcean Platform Support Lead