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Absolutely. One of the main reasons you wouldn’t want to run anything as the root user is if your system is compromised (via one of said applications), the attacker basically has complete access to your machine. No sudo access= decreased potential of catastrophic damage.
You may also want to disable password based authentication on your system as a whole and strictly use key files for authentication. Check out https://www.digitalocean.com/community/tutorials/how-to-install-nginx-on-ubuntu-16-04 as this tutorial covers how to install NGINX and also has a link out to our tutorial on creating user accounts.